If you are looking for a company to partner with you and work with your cell lines, find one that uses cell culture supernatant. This is the medium where the cells are growing, and it is critical to their success. They often centrifugate it to get rid of any debris or floating cells, leaving only the supernatant behind.
AcuSyst Bioreactors
This type of company has Automated Culture Systems (AcuSyst) to provide you with different benefits. First of all, they have single-use disposable cartridges that reduce the labor and cleaning time when you are working on projects. They are scalable because they can add cartridges in parallel, and they continuously manufacture protein. They harvest it and consolidate the upstream process. They use automated monitoring and control to make sure that cells are reproducible. This also decreases contamination and the need for labor. They create in-vivo-like conditions and use cell culture supernatant to improve the quality of cell culture.
Purification and Downstream Processing
This type of company can perform purification and downstream processing for monoclonal antibodies or recombinant protein products. They can use your existing purification process, or they can develop a purification process for your cell culture supernatant and protein. They can work with different protein types, including various species of IgG and IgM monoclonal antibodies.
Cell culture companies also use antibody fragments and derivatives, as well as recombinant proteins. They offer technology transfer, process development, non-GMP manufacturing, process evaluation and validation, and GMP manufacturing support. They can help with your purification process or create one for you.
